What is high content screening technology? How it has open new possibilities to study and analyze cellular processes
Over the past decade, image-based screening as a molecular detection method for cellular assays has opened up a whole new world of possibilities to study the cellular processes in both developing and pre-cancerous tissues. These new techniques combine multiple measurements of cellular physiology, whether it is from sub-cellular levels multicellular organs, or cellular models. As a result, it is easier to study the cellular effects of therapeutic interventions than ever before. There are three main advantages to using image-based screening: it can easily be automated, it is cost-effective, and it offers a large number of potential targets.
When doing the high content screening, it is important to consider
the target cells' composition. This is where image-based screeners become
particularly important because they can be used with any type of tissue, at any
stage in development. There are many ways to study high
content screening in the tissues of pre-cancerous tissues. For example,
fluorescent markers can be used to directly measure DNA content in tissues or
in the membranes of cells; magnetic probes can be used to directly measure
lipid peroxidation in lipid membranes.
In addition, imaging can also be used to measure the level of
cellular organization within cells by imaging changes in cell structure. The
high content screening process can also be used in the pre-clinical laboratory
setting to study the molecular mechanisms of drug action in cell cultures.
Using high content screening to study cellular functions help researchers to
create cell culture models that can be used in drug discovery and development.
It also allow researchers to make use of various experimental designs, such as
independent gene deletion, protein-protein interactions, and co-cultures which
combine different drug types.
Recently, in the United States, Integrated DNA Technologies (IDT)
has partnered with 3CR Bioscience (3CR) to widen access to quality custom
solutions for genotyping screening.
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